Description

n-Fmoc-2,5-Difluoro-L-Phenylalanine is a high-purity, non-natural amino acid derivative designed for advanced peptide synthesis. This compound is a critical building block for the solid-phase synthesis of complex peptides, offering precise control over molecular structure. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, peptidomimetics, and chemical biology probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc-strategy, enabling the controlled assembly of peptide chains.
• Pharmaceutical Research & Development: Used in the synthesis of peptide-based drug candidates, particularly those requiring fluorinated aromatic side chains for enhanced metabolic stability, bioavailability, or binding affinity.
• Chemical Biology: Incorporation into peptide probes and tools to study protein-protein interactions, enzyme function, and cellular processes.
• Peptidomimetic Design: Serves as a scaffold for creating modified peptides with improved pharmacological properties.
• Agrochemical Research: Potential use in the development of novel bioactive peptides for crop protection.
• Material Science: Exploration of fluorinated peptides for creating specialized biomaterials with unique surface properties.

Basic Information

Product Name	n-Fmoc-2,5-Difluoro-L-Phenylalanine
CAS No.	1004959-90-3
Molecular Formula	C24H19F2NO4
Molecular Weight	423.41 g/mol
Synonyms	Fmoc-2,5-difluoro-L-phenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2,5-difluoro-L-phenylalanine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]-3-(2,5-difluorophenyl)propanoic acid; Fmoc-DifluoroPhe(2,5)-OH; Fmoc-2,5-F2-Phe-OH; N-α-Fmoc-2,5-difluoro-L-phenylalanine; 2,5-Difluoro-L-phenylalanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
EINECS	Contact for details

Quality Control

Our n-Fmoc-2,5-Difluoro-L-Phenylalanine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemical and pharmaceutical intermediate production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.5%
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.