Description

2-Chloropyrimidine-5-Boronic Acid Pinacol Ester is a high-value organoboron building block essential for modern synthetic chemistry. This compound matters for its pivotal role in facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecular architectures. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the efficient synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, enabling the creation of complex pyrimidine-based structures.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as those used in OLEDs and organic semiconductors.
• Cross-Coupling Reactions: Specifically designed for Suzuki-Miyaura coupling, enabling the formation of carbon-carbon bonds between the pyrimidine ring and various aryl or vinyl halides.
• Chemical Biology & Probe Development: Utilized in the synthesis of molecular probes and labeled compounds for biochemical and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: A critical reagent for fine chemical manufacturers offering bespoke synthesis services to the life sciences sector.

Basic Information

Product Name	2-Chloropyrimidine-5-Boronic Acid Pinacol Ester
CAS No.	1003845-08-6
Molecular Formula	C11H14BClN2O2
Molecular Weight	252.51 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-chloropyrimidine; 2-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; 2-Chloropyrimidine-5-boronic acid pinacol ester; 2-Chloro-5-pyrimidineboronic acid pinacol ester; (2-Chloropyrimidin-5-yl)boronic acid pinacol ester; Pinacol (2-chloropyrimidin-5-yl)boronate; 1003845-08-6
EINECS	Contact for details

Quality Control

Our 2-Chloropyrimidine-5-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of research and process chemistry. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) and spectroscopic confirmation (NMR) are provided to guarantee traceability and batch-to-batch reliability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.