Description

2-Chloropyrimidine-5-Boronic Acid is a high-value organoboron building block essential for modern synthetic chemistry. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone for constructing complex molecular architectures. This compound is critically needed by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for developing new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel active pharmaceutical ingredients (APIs), especially in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides requiring specific pyrimidine-based scaffolds.
• Material Science: Serves as a precursor for creating organic electronic materials, such as ligands for OLEDs and components for conductive polymers.
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes and bioconjugation reagents for target identification and protein labeling studies.
• Custom Synthesis & Contract Manufacturing: A critical reagent for custom synthesis houses (CROs/CMOs) producing bespoke compounds for client projects.
• Academic & Institutional Research: Fundamental reagent in university and institutional labs for methodological development in cross-coupling and heterocyclic chemistry.

Basic Information

Product Name	2-Chloropyrimidine-5-Boronic Acid
CAS No.	1003845-06-4
Molecular Formula	C4H4BClN2O2
Molecular Weight	158.35 g/mol
Synonyms	(2-Chloropyrimidin-5-yl)boronic acid; 2-Chloro-5-pyrimidineboronic acid; 5-Borono-2-chloropyrimidine; 2-Chloropyrimidine-5-boronic acid pinacol ester (common derivative); 2-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; 1003845-06-4; 2-Chloro-5-pyrimidinylboronic acid
EINECS	Contact for details

Quality Control

Our 2-Chloropyrimidine-5-Boronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and moisture-sensitive nature. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.