Description

4-Bromo-5-Fluoropyrimidine is a high-value halogenated pyrimidine building block essential for modern synthetic chemistry. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where its specific bromo-fluoro substitution pattern enables precise molecular modifications. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides with improved efficacy.
• Material Science Research: Serves as a precursor for creating functionalized organic materials and liquid crystals.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Nucleic Acid Chemistry: Employed in the synthesis of modified nucleosides and nucleotides for biochemical studies.
• Chemical Biology Probes: Used to create labeled compounds and molecular probes for target identification and binding studies.

Basic Information

Product Name	4-Bromo-5-Fluoropyrimidine
CAS No.	1003706-87-3
Molecular Formula	C4H2BrFN2
Molecular Weight	176.97 g/mol
Synonyms	5-Fluoro-4-bromopyrimidine; 4-Bromo-5-fluoropyrimidine; Pyrimidine, 4-bromo-5-fluoro-; 1003706-87-3; 5-Fluoro-4-bromo-pyrimidine; 4-Bromo-5-fluoro-pyrimidine; 4-Bromo-5-fluoro-1,3-diazine
EINECS	Contact for details

Quality Control

Our 4-Bromo-5-Fluoropyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed when not in use to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.