Description

4-Chloro-7-(2-Fluoro-4-(Methylsulfonyl)Phenyl)-6,7-Dihydro-5H-Pyrrolo[2,3-D]Pyrimidine is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is critical for research and development in medicinal chemistry, particularly in the synthesis of targeted kinase inhibitors. It is primarily sought by pharmaceutical companies and contract research organizations (CROs) engaged in the development of novel therapeutics for oncology and inflammatory diseases.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel kinase inhibitor drug candidates.
• Oncology Research: Used in the R&D of small molecule therapeutics targeting specific cancer pathways.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies and lead optimization.
• Preclinical Development: Employed in the production of compounds for pharmacological and toxicological evaluation.
• Contract Manufacturing: Supplied to CDMOs for the scale-up and cGMP production of active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a reference standard or probe in enzymatic assays to study kinase function.

Basic Information

Product Name	4-Chloro-7-(2-Fluoro-4-(Methylsulfonyl)Phenyl)-6,7-Dihydro-5H-Pyrrolo[2,3-D]Pyrimidine
CAS No.	1001397-19-8
Molecular Formula	C₁₅H₁₂ClFN₄O₂S
Molecular Weight	366.80 g/mol
Synonyms	4-Chloro-7-[2-fluoro-4-(methylsulfonyl)phenyl]-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine; 4-Chloro-7-(2-fluoro-4-methanesulfonylphenyl)-5,6,7,8-tetrahydropyrrolo[2,3-d]pyrimidine; 1001397-19-8; Pyrrolo[2,3-d]pyrimidine, 4-chloro-7-[2-fluoro-4-(methylsulfonyl)phenyl]-6,7-dihydro-5H-; 4-Chloro-7-(2-fluoro-4-methylsulfonylphenyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine
EINECS	Contact for details

Quality Control

Our 4-Chloro-7-(2-Fluoro-4-(Methylsulfonyl)Phenyl)-6,7-Dihydro-5H-Pyrrolo[2,3-D]Pyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure it meets the stringent requirements for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.