Description

n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Glycylglycylglycylglycine is a specialized Fmoc-protected tetraglycine peptide building block, essential for the solid-phase synthesis of complex peptides and proteins. This high-purity intermediate is critical for ensuring sequence fidelity and high coupling efficiency in automated peptide synthesis. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of therapeutic peptides, diagnostic reagents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-amino acid derivative for the sequential assembly of peptide chains on resin.
• Therapeutic Peptide Research: Used in the R&D of novel peptide-based pharmaceuticals, including hormone analogs and antimicrobial peptides.
• Bioconjugation & Labeling: Serves as a flexible spacer or linker arm for attaching functional groups, fluorophores, or other molecules to peptides.
• Combinatorial Chemistry: A valuable building block in libraries for high-throughput screening to discover new bioactive compounds.
• Biomaterial Development: Incorporated into engineered peptides for creating hydrogels, scaffolds, and other advanced biomaterials.
• Academic & Industrial Research: Fundamental reagent for studying protein folding, peptide structure-activity relationships (SAR), and biochemical mechanisms.

Basic Information

Product Name	n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Glycylglycylglycylglycine
CAS No.	1001202-16-9
Molecular Formula	C27H30N4O7
Molecular Weight	522.55 g/mol
Synonyms	Fmoc-Gly-Gly-Gly-Gly-OH; Fmoc-Gly4-OH; Fmoc-GGGG-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]tetraglycine; Fmoc-Tetraglycine; (9-Fluorenylmethyloxycarbonyl)-glycylglycylglycylglycine; Nα-Fmoc-tetraglycine; Fmoc-Gly-Gly-Gly-Gly
EINECS	Contact for details

Quality Control

Our n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Glycylglycylglycylglycine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to ensure stereochemical integrity. Certificates of Analysis (COA) detailing all specifications are provided to guarantee compliance with research and pharmaceutical-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be kept under anhydrous conditions. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.