Description

N2-Pivaloyl-4-Chloro-5-Cyano-7H-Pyrrolo[2,3-D]Pyrimidine is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound is critical for research and development in medicinal chemistry, particularly in the creation of kinase inhibitors and other targeted therapeutics. It is an essential building block for pharmaceutical manufacturers and contract research organizations (CROs) focused on oncology and antiviral drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel kinase inhibitors and other small-molecule drugs.
• Oncology Research: Used in the development of targeted cancer therapies that modulate specific cellular pathways.
• Antiviral Drug Development: Serves as a core scaffold for creating compounds with potential activity against viral enzymes.
• Medicinal Chemistry R&D: Employed in structure-activity relationship (SAR) studies to optimize drug candidate potency and selectivity.
• Contract Manufacturing: Supplied to CDMOs for the cGMP production of clinical trial materials and commercial APIs.
• Biochemical Tool Compound: Utilized in biochemical assays to study enzyme function and inhibition mechanisms.

Basic Information

Product Name	N2-Pivaloyl-4-Chloro-5-Cyano-7H-Pyrrolo[2,3-D]Pyrimidine
CAS No.	1000981-99-6
Molecular Formula	C12H11ClN4O
Molecular Weight	262.70 g/mol
Synonyms	4-Chloro-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-2-yl pivalate; 2-Pivaloyloxy-4-chloro-5-cyano-7H-pyrrolo[2,3-d]pyrimidine; 4-Chloro-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-2-yl 2,2-dimethylpropanoate; 1000981-99-6; N2-Pivaloyl-4-chloro-5-cyano-7H-pyrrolo[2,3-d]pyrimidine; 7H-Pyrrolo[2,3-d]pyrimidine, 4-chloro-5-cyano-, 2-(2,2-dimethyl-1-oxopropoxy)-; 4-Chloro-5-cyano-2-pivaloyloxy-7H-pyrrolo[2,3-d]pyrimidine
EINECS	Contact for details

Quality Control

Our N2-Pivaloyl-4-Chloro-5-Cyano-7H-Pyrrolo[2,3-D]Pyrimidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP guidelines for pharmaceutical intermediates, ensuring reliability for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. Handle and store in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.