Description

tert-Butyl (2-Amino-4,5-Difluorophenyl)Carbamate is a high-purity, protected aniline derivative that serves as a critical building block in advanced organic synthesis. Its primary value lies in providing a versatile and reactive aromatic amine scaffold, protected by a Boc (tert-butoxycarbonyl) group, which is essential for constructing complex molecular architectures. This compound is particularly vital for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the difluorophenyl moiety for enhanced biological activity and metabolic stability.
• Peptide Mimetics & PROTACs: Serves as a building block for creating peptide-like molecules and Proteolysis Targeting Chimeras (PROTACs), where the protected amine is crucial for controlled coupling reactions.
• Material Science Research: Employed in the development of advanced polymers and functional materials, such as polyimides or liquid crystals, where aromatic diamines are required.
• Chemical Biology Probes: Utilized as a scaffold for developing fluorescent tags, enzyme inhibitors, and other molecular probes for diagnostic and research applications.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific, high-quality aromatic intermediates.

Basic Information

Product Name	tert-Butyl (2-Amino-4,5-Difluorophenyl)Carbamate
CAS No.	1000698-88-3
Molecular Formula	C11H14F2N2O2
Molecular Weight	244.24 g/mol
Synonyms	2-Amino-4,5-difluorophenyl carbamic acid tert-butyl ester; Boc-2-Amino-4,5-difluoroaniline; N-Boc-2-Amino-4,5-difluoroaniline; tert-Butyl N-(2-amino-4,5-difluorophenyl)carbamate; 2-((tert-Butoxycarbonyl)amino)-4,5-difluoroaniline; 4,5-Difluoro-2-((tert-butoxycarbonyl)amino)aniline; Boc-4,5-difluoro-o-phenylenediamine (protected form)
EINECS	Contact for details

Quality Control

Our tert-Butyl (2-Amino-4,5-Difluorophenyl)Carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent identity. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your R&D and scale-up activities. We adhere to cGMP principles where applicable to meet the stringent requirements of pharmaceutical and advanced chemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability. Keep the container tightly sealed when not in use to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.