Description

2,4-Dichloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine hydrochloride salt is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. This heterocyclic compound serves as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting kinase inhibition. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of potent kinase inhibitors for oncology and inflammatory disease research.
• Chemical Synthesis Building Block: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization programs.
• Research & Development: Essential for academic and industrial R&D labs exploring novel pyridopyrimidine-based compounds.
• API Manufacturing: Employed in the scaled-up production of candidate drugs during clinical trial material preparation.
• Custom Synthesis: Serves as a starting material for contract research organizations (CROs) and CDMOs offering bespoke chemical synthesis services.

Basic Information

Product Name	2,4-Dichloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine hydrochloride salt
CAS No.	1000578-08-4
Molecular Formula	C7H8Cl3N3
Molecular Weight	248.52 g/mol
Synonyms	2,4-Dichloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine HCl; 2,4-Dichloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine hydrochloride; 5,6,7,8-Tetrahydro-2,4-dichloropyrido[3,4-d]pyrimidine hydrochloride; 2,4-Dichloro-7,8-dihydro-5H-pyrido[3,4-d]pyrimidine hydrochloride; CAS 1000578-08-4
EINECS	Contact for details

Quality Control

Our 2,4-Dichloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine hydrochloride salt is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical research. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles as determined by advanced analytical techniques including HPLC, NMR, and mass spectrometry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.