Description

2,3,4-Trifluoro-6-Aminobromobenzene is a high-value, multi-functional halogenated aniline derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both bromine and fluorine substituents adjacent to an amine group, makes it an indispensable intermediate for creating complex molecules with tailored properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials sectors for constructing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated drug candidates, particularly for central nervous system (CNS) agents, antibiotics, and kinase inhibitors where fluorine atoms enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used to construct novel herbicides, fungicides, and pesticides, leveraging the fluorine and bromine groups to improve lipophilicity and target binding.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated aromatic cores in electronic display materials and organic light-emitting diodes (OLEDs), contributing to improved charge transport and thermal stability.
• Polymer Modification: Incorporated as a monomer or cross-linking agent to introduce fluorine into polymer backbones, enhancing chemical resistance, lowering dielectric constants, and improving material performance.
• Cross-Coupling Reactions: The bromine atom is an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira), enabling rapid diversification of the benzene core.
• Chemical Research & Development: Employed in academic and industrial labs for exploring new synthetic methodologies and creating libraries of fluorinated compounds for high-throughput screening.

Basic Information

Product Name	2,3,4-Trifluoro-6-Aminobromobenzene
CAS No.	1000577-24-1
Molecular Formula	C6H2BrF3N
Molecular Weight	227.99 g/mol
Synonyms	2-Amino-3,4,5-trifluorobromobenzene; 6-Bromo-2,3,4-trifluoroaniline; 2,3,4-Trifluoro-6-bromoaniline; 1-Bromo-2,3,4-trifluoro-6-aminobenzene; 2-Bromo-3,4,5-trifluoroaniline; (3,4,5-Trifluoro-2-bromophenyl)amine; 2,3,4-Trifluoroaniline-6-bromide
EINECS	Contact for details

Quality Control

Every batch of 2,3,4-Trifluoro-6-Aminobromobenzene is manufactured and tested under a strict quality management system. We ensure compliance with relevant industry standards and provide comprehensive analytical data. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for each lot upon request. Our quality protocols are designed to meet the rigorous demands of GMP and ISO environments for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage and handling.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.