Description

3-Chloro-4-(Trifluoromethoxy)Phenol is a high-purity, halogenated phenolic compound that serves as a critical advanced intermediate in modern chemical synthesis. Its unique structure, featuring both chloro and trifluoromethoxy substituents, makes it a valuable building block for introducing specific steric and electronic properties into target molecules. This compound is essential for research and development chemists and process engineers in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients with enhanced performance characteristics.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in the synthesis of molecules targeting central nervous system (CNS) disorders, anti-inflammatory agents, and antimicrobials.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, where the trifluoromethoxy group can improve metabolic stability and bioavailability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of specialized fluorinated compounds for electronic applications, including liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs).
• Polymer Modification: Acts as a functional monomer or additive to impart specific properties like flame retardancy, chemical resistance, or altered solubility to advanced polymer systems.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to construct complex, multi-functional aromatic systems in academic and industrial R&D.
• Dye & Pigment Intermediate: Utilized in the synthesis of specialized dyes and pigments where halogen and fluorine atoms are required for color fastness and specific spectral properties.

Basic Information

Product Name	3-Chloro-4-(Trifluoromethoxy)Phenol
CAS No.	1000339-94-5
Molecular Formula	C7H4ClF3O2
Molecular Weight	212.56 g/mol
Synonyms	3-Chloro-4-(trifluoromethoxy)phenol; 4-Trifluoromethoxy-3-chlorophenol; 3-Chloro-α,α,α-trifluoro-p-cresol; Phenol, 3-chloro-4-(trifluoromethoxy)-; 1-Chloro-2-hydroxy-5-(trifluoromethoxy)benzene; 2-Chloro-1-hydroxy-4-(trifluoromethoxy)benzene; 3-Chloro-4-hydroxy(trifluoromethoxy)benzene
EINECS	Contact for details

Quality Control

Our 3-Chloro-4-(Trifluoromethoxy)Phenol is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for your critical syntheses. We employ advanced analytical techniques, including HPLC, GC, NMR, and MS, to verify identity, purity, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated research and development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container must be kept tightly closed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.