Description

Fmoc-Ser(Tbu)-Ser(Psime,Mepro)-Oh is a specialized, orthogonally protected dipeptide building block designed for advanced solid-phase peptide synthesis (SPPS). This compound matters for its critical role in enabling the complex synthesis of peptides containing serine residues with specific side-chain modifications, ensuring high coupling efficiency and minimal side reactions. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on developing novel therapeutic peptides, peptide mimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the automated or manual assembly of complex peptide sequences.
• Pharmaceutical Research: Building block for the discovery and development of peptide-based drugs targeting GPCRs, enzymes, and other biological pathways.
• Peptide Mimetic Development: Used to incorporate modified serine analogs that enhance metabolic stability, bioavailability, or binding affinity.
• Bioconjugation and Probe Synthesis: Serves as a precursor for creating labeled peptides for diagnostic imaging, biomarker discovery, and biochemical assays.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening against therapeutic targets.
• Academic Research: Essential reagent for studying protein-protein interactions, enzyme mechanisms, and post-translational modifications in a controlled manner.

Basic Information

Product Name	Fmoc-Ser(Tbu)-Ser(Psime,Mepro)-Oh
CAS No.	1000164-43-1
Molecular Formula	C31H42N2O8Si
Molecular Weight	598.77 g/mol
Synonyms	Fmoc-Ser(tBu)-Ser[Psi(Me,Pro)]-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-(tert-butyl)-L-seryl-N-[(1S)-1-[(1-methylethoxy)carbonyl]propyl]-L-serinamide; Fmoc-Ser(O-tBu)-Ser[Psi(Me,Pro)]-OH; Fmoc-L-Ser(tBu)-L-Ser[Psi(Me,Pro)]-OH; Protected Dipeptide Fmoc-Ser(tBu)-Ser[Psi]; Pseudoproline Dipeptide Building Block; Fmoc-Ser(tBu)-Ser(ψMe,Pro)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-Ser(Tbu)-Ser(Psime,Mepro)-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and MS for identity verification, to ensure it meets the high standards required for sensitive peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥ 95.0% (Area Percent)
Water Content (KF)	≤ 1.0%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.