Description

2(Bis-(Hydroxyethyl)Amino)-6-(4-Methoxybenzylamino)-9-Isopropyl-Purine is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound is valued for its role as a key building block in the synthesis of novel therapeutic agents, particularly within the field of kinase inhibitor development. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in producing targeted cancer therapies and other specialized active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of purine-based kinase inhibitors for oncology research and drug development.
• Biochemical Research: Used as a reference standard or a tool compound in enzymatic assays and biological pathway studies related to cell signaling.
• API Synthesis: Serves as a core structural component for manufacturing investigational new drugs (INDs) and novel chemical entities (NCEs).
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.
• Academic Research: Utilized in university and institutional laboratories for medicinal chemistry projects and structure-activity relationship (SAR) studies.

Basic Information

Product Name	2(Bis-(Hydroxyethyl)Amino)-6-(4-Methoxybenzylamino)-9-Isopropyl-Purine
CAS No.	199986-75-9
Molecular Formula	C20H29N7O3
Molecular Weight	415.49 g/mol
Synonyms	9-Isopropyl-2-[bis(2-hydroxyethyl)amino]-6-[(4-methoxyphenyl)methylamino]purine; 2-[Bis(2-hydroxyethyl)amino]-6-[(4-methoxybenzyl)amino]-9-(propan-2-yl)-9H-purine; 2-(Bis(2-hydroxyethyl)amino)-6-((4-methoxybenzyl)amino)-9-isopropyl-9H-purine; 9H-Purine, 2-[bis(2-hydroxyethyl)amino]-6-[(4-methoxyphenyl)methyl]amino]-9-(1-methylethyl)-; 2-(N,N-Bis(2-hydroxyethyl)amino)-6-(4-methoxybenzylamino)-9-isopropylpurine; Kinase Inhibitor Intermediate; Purine Derivative CAS 199986-75-9
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and high purity suitable for pharmaceutical research. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. We support development under cGMP guidelines for projects requiring regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic nature, store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place. Recommended long-term storage temperature is 2-8°C. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.