Description

4-Amino-L-Phenylalanine Hydrate is a high-purity, non-natural amino acid derivative of significant interest in advanced pharmaceutical and biochemical research. This compound serves as a critical chiral building block for the synthesis of complex peptides and active pharmaceutical ingredients (APIs). It is particularly valuable for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors seeking to develop novel therapeutics and diagnostic agents. Its defined stereochemistry and functional groups make it an essential precursor in targeted drug discovery programs.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the production of novel peptide-based drugs and active pharmaceutical ingredients (APIs).
• Bioconjugation & Probe Synthesis: Used in the development of fluorescent probes, affinity labels, and antibody-drug conjugates (ADCs) due to its reactive amino group.
• Peptide Chemistry: Serves as a specialized building block in solid-phase and solution-phase peptide synthesis (SPPS) to introduce unique structural motifs.
• Enzyme Inhibitor Research: A precursor for designing and synthesizing inhibitors targeting specific enzymes and biological pathways.
• Chemical Biology Studies: Employed in the study of protein-protein interactions and cellular processes through site-specific incorporation.
• Standards & Reference Materials: Used as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	4-Amino-L-Phenylalanine Hydrate
CAS No.	199926-19-7
Molecular Formula	C9H12N2O2 • xH2O
Molecular Weight	180.20 (Anhydrous basis)
Synonyms	(2S)-2-Amino-3-(4-aminophenyl)propanoic acid hydrate; L-4-Aminophenylalanine hydrate; 4-Amino-DL-phenylalanine hydrate (related); p-Amino-L-phenylalanine hydrate; 4-Amino-L-Phe-OH • H2O; 4-Amino-L-α-aminohydrocinnamic acid hydrate; Fmoc-4-Amino-L-Phe-OH (protected derivative); AAPH
EINECS	Contact for details

Quality Control

Our 4-Amino-L-Phenylalanine Hydrate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We support compliance with relevant guidelines for pharmaceutical intermediates and can provide material for GMP applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-Isomer)
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.