Description

4-(4-Fluoro-1-Naphthalenyl)-6-(1-Methylethyl)-2-Pyrimidinamine Hydrochloride is a high-purity, non-nucleoside reverse transcriptase inhibitor (NNRTI) intermediate with significant pharmaceutical relevance. This compound is critical for research and development in antiviral drug discovery, particularly targeting HIV-1. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of advanced therapeutic agents.

Application

• Key Pharmaceutical Intermediate for the synthesis of next-generation Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs).
• Research & Development of novel antiviral agents, specifically for HIV-1 treatment protocols.
• Process Chemistry and scale-up studies in fine chemical and API (Active Pharmaceutical Ingredient) manufacturing.
• Biochemical Research for studying enzyme inhibition mechanisms and structure-activity relationships (SAR).
• Reference Standard for analytical method development and quality control in pharmaceutical production.

Basic Information

Product Name	4-(4-Fluoro-1-Naphthalenyl)-6-(1-Methylethyl)-2-Pyrimidinamine Hydrochloride
CAS No.	199864-87-4
Molecular Formula	C₁₇H₁₇FN₄·HCl
Molecular Weight	332.80 g/mol (Free base)
Synonyms	4-(4-Fluoronaphthalen-1-yl)-6-isopropylpyrimidin-2-amine hydrochloride; 6-Isopropyl-4-(4-fluoro-1-naphthyl)pyrimidin-2-amine hydrochloride; NNRTI Intermediate; R120393 Intermediate; Capravirine Intermediate; S-1153 Intermediate; AG1549 Intermediate; PNU-142721 Intermediate
EINECS	Contact for details

Quality Control

Our 4-(4-Fluoro-1-Naphthalenyl)-6-(1-Methylethyl)-2-Pyrimidinamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.