Description

[4-(Difluoromethoxy)-3-Methoxyphenyl]Methanol is a high-value fluorinated aromatic building block characterized by its difluoromethoxy and methoxy substituents. This compound is essential for the synthesis of advanced pharmaceutical intermediates and agrochemicals, where its unique fluorine-containing moiety can significantly alter biological activity and metabolic stability. It is primarily sought by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and anti-inflammatory drugs.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, where the difluoromethoxy group enhances lipophilicity and target binding.
• Liquid Crystal Materials: Serves as a precursor for fluorinated components in liquid crystal displays (LCDs), improving dielectric anisotropy and stability.
• Organic Electronics: Employed in the synthesis of fluorinated organic semiconductors and charge-transport materials for OLEDs and OFETs.
• Advanced Material Research: Acts as a versatile building block for creating novel polymers and coatings with specific surface properties and chemical resistance.
• Chemical Biology Probes: Utilized in the design of fluorinated probes and tags for studying biological mechanisms and drug-target interactions.

Basic Information

Product Name	[4-(Difluoromethoxy)-3-Methoxyphenyl]Methanol
CAS No.	199854-38-1
Molecular Formula	C9H10F2O3
Molecular Weight	204.17 g/mol
Synonyms	4-(Difluoromethoxy)-3-methoxybenzyl alcohol; (4-(Difluoromethoxy)-3-methoxyphenyl)methanol; 3-Methoxy-4-(difluoromethoxy)benzyl alcohol; α-Hydroxymethyl-4-(difluoromethoxy)-3-methoxybenzene; 1-[4-(Difluoromethoxy)-3-methoxyphenyl]methanol; DFMMBA; Benzyl alcohol, 4-(difluoromethoxy)-3-methoxy-
EINECS	Contact for details

Quality Control

Our [4-(Difluoromethoxy)-3-Methoxyphenyl]Methanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent oxidation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.