Description

Cilengitide Methanesulfonate is a high-purity, non-peptidic cyclic RGD pentapeptide antagonist that selectively inhibits the αvβ3 and αvβ5 integrins. This compound is of significant interest for its potent anti-angiogenic and anti-tumor properties, making it a critical research tool in oncology and vascular biology. It is primarily utilized by pharmaceutical researchers, academic institutions, and R&D laboratories focused on developing novel cancer therapeutics and studying cell adhesion mechanisms.

Application

• Pharmaceutical R&D: A key reference standard and active pharmaceutical ingredient (API) intermediate in preclinical and clinical research for anti-cancer drugs.
• Angiogenesis Inhibition Studies: Used to investigate pathways of tumor-induced blood vessel formation (angiogenesis) and evaluate potential anti-angiogenic agents.
• Integrin Receptor Research: Serves as a selective antagonist in biochemical and cellular assays to study the role of αvβ3 and αvβ5 integrins in metastasis, apoptosis, and cell signaling.
• Cell Adhesion & Migration Assays: Employed to inhibit integrin-mediated cell adhesion, spreading, and migration on extracellular matrix proteins like vitronectin.
• In Vivo Model Studies: Utilized in animal models of cancer (e.g., glioblastoma, melanoma) to assess efficacy, pharmacokinetics, and pharmacodynamics of integrin-targeting therapies.
• Formulation Development: Acts as a model compound in developing novel drug delivery systems for peptide-based therapeutics.

Basic Information

Product Name	Cilengitide Methanesulfonate
CAS No.	199807-38-0
Molecular Formula	C₃₄H₆₀N₁₂O₁₀S₂
Molecular Weight	849.06 g/mol
Synonyms	EMD 121974; Cyclo(-Arg-Gly-Asp-D-Phe-N(Me)Val-); Cilengitide mesylate; (Cyclo(Arg-Gly-Asp-D-Phe-N-methyl-Val)) Methanesulfonate; EMD121974-N-1; NSC 707544; Integrin αvβ3 antagonist; RGD cyclic pentapeptide methanesulfonate
EINECS	Contact for details

Quality Control

Our Cilengitide Methanesulfonate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and tests for residual solvents and heavy metals, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting compliance with cGMP guidelines for API intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC-MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤2.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.