Description

Fmoc-L-4,4'-Biphenylalanine is a protected, non-natural amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound is specifically engineered to introduce the rigid, aromatic 4,4'-biphenyl moiety into peptide chains, a modification critical for modulating peptide conformation, stability, and receptor binding affinity. It is a vital building block for researchers and manufacturers in pharmaceutical development, biotechnology, and advanced materials science who require high-purity, reliable intermediates for creating novel therapeutic peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a fundamental reagent for the automated, stepwise construction of custom peptide sequences.
• Pharmaceutical Research & Development: Used to synthesize peptide-based drug candidates, particularly those targeting protein-protein interactions where the biphenyl group enhances binding and metabolic stability.
• Bioconjugation & Probe Development: Serves as a precursor for creating fluorescent or affinity-labeled peptides for diagnostic assays and biochemical studies.
• Material Science: Incorporation into bio-inspired polymers and supramolecular structures to leverage the self-assembly and electronic properties of the biphenyl unit.
• Chemical Biology: A key tool for studying enzyme-substrate interactions and designing peptide inhibitors with tailored physicochemical properties.

Basic Information

Product Name	Fmoc-L-4,4'-Biphenylalanine
CAS No.	199110-64-0
Molecular Formula	C30H25NO4
Molecular Weight	463.52 g/mol
Synonyms	Fmoc-Bip(4,4')-Ala-OH; Fmoc-4,4'-Biphenyl-L-alanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4,4'-biphenyl-L-alanine; (2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-[1,1'-biphenyl]-4-ylpropanoic acid; Fmoc-L-Biphenyl(4,4')alanine; Fmoc-4,4'-Biphenylalanine; N-Fmoc-4,4'-biphenyl-L-alanine; Fmoc-Bip(4,4')-Ala
EINECS	Contact for details

Quality Control

Our Fmoc-L-4,4'-Biphenylalanine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the stringent requirements for peptide synthesis. A Certificate of Analysis (COA) detailing purity, specific rotation, and chromatographic data is provided with each shipment to guarantee reproducible performance in your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.