Description

L-Propargylglycine Hcl CAS NO 198774-27-5 is a high-purity, non-proteinogenic amino acid derivative featuring a propargyl side chain, making it a valuable biochemical building block and research reagent. Its unique structure provides a versatile handle for bioorthogonal chemistry, particularly in click chemistry applications for labeling and conjugation. This compound is essential for researchers and manufacturers in pharmaceutical development, proteomics, and chemical biology who require reliable, high-quality intermediates for advanced synthesis.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly those targeting enzyme inhibition.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, especially for enzymes involved in amino acid metabolism.
• Proteomics & Chemical Biology: Serves as a critical reagent for bioorthogonal labeling via copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry, enabling the study of protein function and localization.
• Peptide Synthesis: Incorporated into custom peptides to introduce alkyne functional groups for subsequent modification or conjugation with fluorescent dyes, biotin, or other molecules.
• Metabolomics Studies: Employed as a metabolic probe to investigate pathways and disruptions in amino acid utilization within biological systems.
• Academic & Industrial R&D: A fundamental tool for discovery research in medicinal chemistry, molecular biology, and diagnostic assay development.

Basic Information

Product Name	L-Propargylglycine Hcl
CAS No.	198774-27-5
Molecular Formula	C5H8ClNO2
Molecular Weight	149.57 g/mol
Synonyms	(S)-2-Amino-4-pentynoic acid hydrochloride; L-2-Amino-4-pentynoic acid hydrochloride; Propargylglycine hydrochloride, L-; (S)-2-Amino-pent-4-ynoic acid hydrochloride; L-APA HCl; 4-Pentynoic acid, 2-amino-, hydrochloride, (2S)-; 2-Amino-4-pentynoic acid hydrochloride (L-); L-2-Amino-4-pentynoate hydrochloride
EINECS	Contact for details

Quality Control

Our L-Propargylglycine HCl is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and chiral purity, to meet rigorous research and development standards. A Certificate of Analysis (COA) detailing specific results for identity, purity, and impurities is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-Isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.