Description

2-(Trifluoromethoxy)Benzyl Bromide CAS NO 198649-68-2 is a versatile and high-value organobromide building block characterized by the presence of both a reactive benzyl bromide group and a stable, lipophilic trifluoromethoxy substituent. This unique molecular structure makes it a critical intermediate for the synthesis of advanced pharmaceutical compounds and agrochemicals, where it introduces key pharmacophores and modulates physicochemical properties. It is primarily sought after by research and development chemists and process scale-up teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) drugs, anti-inflammatory agents, and antiviral compounds.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science: Employed in the synthesis of monomers for specialty polymers and liquid crystals, imparting unique electronic and solubility characteristics.
• Chemical Biology Probes: Useful for the preparation of molecular probes and tags for studying biological systems and drug-target interactions.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up manufacturing under cGMP conditions for clinical trial materials.

Basic Information

Product Name	2-(Trifluoromethoxy)Benzyl Bromide
CAS No.	198649-68-2
Molecular Formula	C8H6BrF3O
Molecular Weight	255.04 g/mol
Synonyms	α-Bromo-2-(trifluoromethoxy)toluene; 1-(Bromomethyl)-2-(trifluoromethoxy)benzene; (2-(Trifluoromethoxy)phenyl)methyl bromide; o-(Trifluoromethoxy)benzyl bromide; 2-(Trifluoromethoxy)benzylbromide; Benzene, 1-(bromomethyl)-2-(trifluoromethoxy)-; Bromomethyl(2-trifluoromethoxyphenyl)ether
EINECS	Contact for details

Quality Control

Our 2-(Trifluoromethoxy)Benzyl Bromide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets the highest standards of purity and consistency required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment. We support development and commercial projects with specifications tailored to meet cGMP, ICH guidelines, and other relevant regulatory frameworks upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to maintain stability and purity. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.