Description

Fmoc-n-Methyl-o-Benzyl-L-Threonine CAS NO 198561-81-8 is a protected, non-proteinogenic amino acid derivative designed for advanced solid-phase peptide synthesis (SPPS). This compound is critical for introducing the unique structural and functional properties of methylated threonine into peptide chains, enabling the research and development of novel bioactive molecules. It is an essential building block for pharmaceutical researchers, medicinal chemists, and biotech companies focused on peptide-based drug discovery, proteomics, and the synthesis of complex peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/t-Bu strategy, facilitating the controlled assembly of complex peptide sequences.
• Pharmaceutical Research & Development: Used in the synthesis of peptide therapeutics, hormones, and enzyme inhibitors where site-specific methylation is required for activity or stability.
• Medicinal Chemistry: Enables the creation of peptide analogs and mimetics to study structure-activity relationships (SAR) and improve pharmacokinetic properties.
• Bioconjugation and Labeling: Serves as a specialized precursor for introducing functional handles or labels into peptides at specific positions.
• Academic & Institutional Research: Supports fundamental studies in chemical biology, protein engineering, and post-translational modification mimicry.
• Production of Custom Peptides: A critical raw material for CROs and CDMOs offering bespoke peptide synthesis services for clients worldwide.

Basic Information

Product Name	Fmoc-n-Methyl-o-Benzyl-L-Threonine
CAS No.	198561-81-8
Molecular Formula	C27H27NO5
Molecular Weight	445.51 g/mol
Synonyms	Fmoc-N-Me-Thr(Bzl)-OH; Fmoc-N-Methyl-O-benzyl-L-threonine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-O-(phenylmethyl)-L-threonine; (2S,3R)-3-(Benzyloxy)-2-[(9H-fluoren-9-ylmethoxy)carbonyl(methyl)amino]butanoic acid; Fmoc-N-methyl-Thr(Bzl)-OH; N-Fmoc-N-methyl-O-benzyl-L-threonine; Fmoc-N-Me-Thr(OBzl)-OH; Fmoc-N-Me-Thr(Bn)-OH
EINECS	Contact for details

Quality Control

Every batch of Fmoc-n-Methyl-o-Benzyl-L-Threonine is manufactured and tested under strict quality management systems. We guarantee high chemical purity and chiral integrity, which are critical for successful peptide synthesis. Comprehensive analytical testing, including HPLC, NMR, and optical rotation, is performed to ensure the product meets exacting specifications for research and cGMP applications. A detailed Certificate of Analysis (COA) is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and under an inert atmosphere to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.