Description

Fmoc-L-Propargylglycine is a non-natural, side-chain functionalized amino acid derivative designed for solid-phase peptide synthesis (SPPS). This compound matters as a critical building block for introducing bioorthogonal alkyne handles into synthetic peptides and proteins, enabling downstream conjugation via click chemistry. It is primarily needed by researchers and manufacturers in pharmaceutical R&D, chemical biology, and bioconjugation for developing novel drug candidates, probes, and biomaterials.

Application

• Solid-phase peptide synthesis (SPPS) for incorporating alkyne functional groups.
• Chemical biology research for site-specific labeling of peptides and proteins via copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• Preparation of peptide-drug conjugates (PDCs) and antibody-drug conjugates (ADCs) with defined linkage sites.
• Development of activity-based probes (ABPs) and imaging agents for proteomic studies.
• Material science applications, such as creating functionalized peptide-based polymers and hydrogels.
• As a key intermediate in the synthesis of more complex, modified peptide architectures.

Basic Information

Product Name	Fmoc-L-Propargylglycine
CAS No.	198561-07-8
Molecular Formula	C₂₁H₁₉NO₄
Molecular Weight	349.38 g/mol
Synonyms	Fmoc-L-2-amino-5-hexynoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-2-amino-5-hexynoic acid; Fmoc-L-homopropargylglycine-OH; Fmoc-L-Hpg-OH; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)hex-5-ynoic acid; N-α-Fmoc-L-propargylglycine; Fmoc-L-2-amino-hex-5-ynoic acid; Fmoc-L-α-amino-δ-hexynoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-L-Propargylglycine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic identification. Certificates of Analysis (COA) with detailed specifications are provided to ensure the material meets the high standards required for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.