Description

Fmoc-L-Thiazolidine-4-Carboxylic Acid CAS NO 198545-89-0 is a specialized, high-purity amino acid derivative used as a critical building block in solid-phase peptide synthesis (SPPS). Its primary value lies in the Fmoc protecting group, which allows for orthogonal deprotection strategies essential for constructing complex peptides. This compound is indispensable for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors developing novel peptide-based therapeutics, diagnostics, and research tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/t-Bu strategy, enabling the sequential assembly of peptide chains.
• Pharmaceutical Intermediates: Used in the research and development of peptide drugs, including hormone analogs, antimicrobial peptides, and enzyme inhibitors.
• Bioconjugation: Serves as a precursor for creating peptide-based conjugates for targeted drug delivery systems.
• Chemical Biology Probes: Incorporated into peptides used to study protein-protein interactions, enzyme activity, and cellular pathways.
• Combinatorial Chemistry Libraries: A valuable building block for generating diverse peptide libraries for high-throughput screening in drug discovery.
• Academic & Industrial Research: Fundamental reagent for synthetic chemistry and peptide science research in universities and R&D centers.

Basic Information

Product Name	Fmoc-L-Thiazolidine-4-Carboxylic Acid
CAS No.	198545-89-0
Molecular Formula	C19H17NO4S
Molecular Weight	355.41 g/mol
Synonyms	Fmoc-Thz-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-thiazolidine-4-carboxylic acid; (4R)-1,3-Thiazolidine-4-carboxylic acid, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-; Fmoc-L-thiazolidine-4-carboxylate; Fmoc-Thiazolidine-4-Carboxylic Acid; N-Fmoc-L-thiazolidine-4-carboxylic acid; Fmoc-L-Thz-OH; N-α-Fmoc-L-thiazolidine-4-carboxylic acid
EINECS	Contact for details

Quality Control

Our Fmoc-L-Thiazolidine-4-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach ambient temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Specific Rotation	-50.0° to -55.0° (c=1, DMF)
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.