Description

Fmoc-D-Pentafluorophenylalanine is a high-purity, non-natural amino acid derivative designed for advanced peptide synthesis. This compound is essential for introducing the unique steric and electronic properties of a pentafluorophenyl group into peptide chains, which can dramatically influence binding affinity and metabolic stability. It is a critical building block for researchers and manufacturers in pharmaceutical development, particularly for creating novel peptide-based therapeutics, diagnostics, and chemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc-strategy, enabling the incorporation of D-Pentafluorophenylalanine into peptide sequences.
• Pharmaceutical Research: Used in the development of peptide drugs where enhanced receptor selectivity, improved bioavailability, or altered pharmacokinetic profiles are required.
• Chemical Biology & Proteomics: Serves as a tool for studying protein-protein interactions and enzyme mechanisms by acting as a fluorinated probe or a site-specific label.
• Material Science: Exploration of fluorinated peptides for creating novel bio-interfaces and surfaces with specific chemical properties.
• Agrochemical Development: Potential use in the synthesis of bioactive peptide mimetics for crop protection agents.
• Academic Research: Fundamental studies in organic chemistry and medicinal chemistry focused on fluorine chemistry and peptide structure-activity relationships.

Basic Information

Product Name	Fmoc-D-Pentafluorophenylalanine
CAS No.	198545-85-6
Molecular Formula	C24H16F5NO4
Molecular Weight	477.38 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-pentafluorophenylalanine; Fmoc-D-Phe(2,3,4,5,6-F5)-OH; Fmoc-D-Pentafluorophenylalanine-OH; (2R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(pentafluorophenyl)propanoic acid; N-Fmoc-D-pentafluorophenylalanine; Fmoc-D-Phe(F5)-OH; D-Fmoc-Pentafluorophenylalanine
EINECS	Contact for details

Quality Control

Our Fmoc-D-Pentafluorophenylalanine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for sensitive peptide synthesis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (D-isomer)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.