Description

Pyrimidine, 5-(Bromomethyl)-2-(Trifluoromethyl)- (9Ci) is a high-value, multi-functional heterocyclic building block designed for advanced synthetic chemistry. This compound matters for its unique trifluoromethyl and bromomethyl functional groups, which enable precise molecular modifications critical for developing novel active ingredients. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating new drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Material Science Research: Serves as a precursor for synthesizing specialized ligands, catalysts, and functional monomers used in advanced polymers and electronic materials.
• Fluorine Chemistry: An essential building block in medicinal and agricultural chemistry for introducing fluorine atoms to modulate lipophilicity, metabolic stability, and bioavailability.
• Cross-Coupling Reactions: The bromomethyl moiety makes it a suitable substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to construct complex molecular architectures.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.

Basic Information

Product Name	Pyrimidine, 5-(Bromomethyl)-2-(Trifluoromethyl)- (9Ci)
CAS No.	198404-35-2
Molecular Formula	C6H4BrF3N2
Molecular Weight	241.01 g/mol
Synonyms	5-(Bromomethyl)-2-(trifluoromethyl)pyrimidine; 2-(Trifluoromethyl)-5-(bromomethyl)pyrimidine; 5-Bromomethyl-2-trifluoromethylpyrimidine; 2-Trifluoromethyl-5-bromomethylpyrimidine; Pyrimidine, 5-(bromomethyl)-2-(trifluoromethyl)-; (5-Bromomethyl-2-trifluoromethyl)pyrimidine
EINECS	Contact for details

Quality Control

Our Pyrimidine, 5-(Bromomethyl)-2-(Trifluoromethyl)- (9Ci) is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with exacting R&D and process chemistry standards. Certificates of Analysis (COA) with detailed batch-specific data are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.