Description

Biotinyl-Pth (44-68) (Human) is a synthetic peptide fragment, specifically the 44-68 sequence of the human parathyroid hormone (PTH), modified with a biotin label. This biotinylation is critical for enabling highly sensitive detection, isolation, and quantification in advanced biochemical assays. It is an essential research-grade reagent for scientists in pharmaceutical R&D and academic institutions studying bone metabolism, calcium homeostasis, and endocrine disorders. The compound is supplied under stringent quality control to ensure batch-to-batch consistency for reliable experimental results.

Application

• Biomarker Research & Assay Development: Used as a calibrated standard or capture reagent in immunoassays (e.g., ELISA) to study PTH-related pathways.
• Drug Discovery & Screening: Serves as a key ligand in high-throughput screening (HTS) platforms to identify novel therapeutics for osteoporosis and hyperparathyroidism.
• Affinity Purification & Pull-Down Assays: The biotin tag facilitates streptavidin/avidin-based purification of interacting proteins or antibodies for proteomics research.
• Diagnostic Kit Manufacturing: Employed as a critical raw material in the production of in-vitro diagnostic (IVD) kits for PTH measurement.
• Structural & Functional Studies: Utilized in biophysical studies to map receptor-binding epitopes and understand PTH fragment activity.
• Quality Control Reference: Acts as a reference standard for the quality control of PTH-based pharmaceuticals and diagnostic reagents.

Basic Information

Product Name	Biotinyl-Pth (44-68) (Human)
CAS No.	198341-96-7
Molecular Formula	C₁₄₇H₂₄₀N₄₄O₄₅S
Molecular Weight	~3326.8 g/mol
Synonyms	Biotinylated PTH (44-68), Human; Biotin-PTH(44-68); Biotinyl-Parathyroid Hormone (44-68); PTH (44-68)-Biotin; Biotinylated Parathyroid Hormone Fragment 44-68; H-Biotinyl-Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe-OH; Biotinyl-hPTH(44-68)
EINECS	Contact for details

Quality Control

Our Biotinyl-Pth (44-68) (Human) is manufactured under controlled conditions to meet the exacting standards of life science research. Every batch is subjected to rigorous analytical testing, including HPLC for purity verification and mass spectrometry (MS) for identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, peptide content, and solvent residues is provided to ensure full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Analysis	Within ± 10% of theoretical
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.