Description

2-Nitro-4-(Pentafluorosulphanyl)Aniline, also known as 2-Amino-5-(Pentafluorothio)Nitrobenzene, is a high-value, multi-functional aromatic building block distinguished by its unique combination of nitro, amino, and pentafluorosulfanyl (SF5) functional groups. This compound is critical for advanced research and development, enabling the synthesis of novel materials and active ingredients with tailored electronic and steric properties. It is primarily sought after by pharmaceutical, agrochemical, and specialty chemical manufacturers for creating next-generation products requiring enhanced stability, lipophilicity, and bioactivity.

Application

• Pharmaceutical Intermediate: A key synthon for developing novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Research: Used in the synthesis of advanced herbicides, fungicides, and insecticides, where the SF5 group can improve metabolic stability and membrane permeability.
• Liquid Crystal & OLED Materials: Serves as a precursor for electron-deficient components in electronic materials, contributing to the development of high-performance displays and organic semiconductors.
• Polymer & Material Science: Incorporated into specialty polymers and high-performance resins to impart unique thermal, chemical, and surface properties.
• Dye & Pigment Synthesis: Acts as an intermediate for creating novel, light-fast dyes and functional pigments with specific coloristic and application properties.
• Ligand & Catalyst Development: Utilized in organometallic chemistry to create novel ligands for catalysis, leveraging the strong electron-withdrawing nature of the SF5 group.

Basic Information

Product Name	2-Nitro-4-(Pentafluorosulphanyl)Aniline / 2-Amino-5-(Pentafluorothio)Nitrobenzene
CAS No.	197385-06-1
Molecular Formula	C6H3F5N2O2S
Molecular Weight	262.16 g/mol
Synonyms	4-Amino-3-nitrobenzenesulfonyl pentafluoride; 2-Nitro-4-(pentafluorosulfanyl)benzenamine; 2-Amino-5-(pentafluorosulfanyl)nitrobenzene; 4-(Pentafluorosulfanyl)-2-nitroaniline; 5-Amino-2-nitro-1-(pentafluorosulfanyl)benzene; SF5-Aniline derivative; Pentafluorosulfanyl aniline nitro derivative; CAS 197385-06-1
EINECS	Contact for details

Quality Control

Our production of 2-Nitro-4-(Pentafluorosulphanyl)Aniline adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and GC/MS for residual solvent analysis. We provide detailed Certificates of Analysis (COA) with each shipment, ensuring traceability and compliance with your internal specifications and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.