Description

Fmoc-D-2-Me-Trp CAS NO 196808-79-4 is a high-purity, non-natural amino acid derivative specifically engineered for solid-phase peptide synthesis (SPPS). This compound is critical for the precise incorporation of the D-isomer of 2-methyltryptophan into peptide chains, enabling researchers to modulate peptide conformation, stability, and biological activity. It is an essential building block for pharmaceutical R&D, particularly in the development of novel therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated synthesis of complex peptides.
• Pharmaceutical Research: Incorporation into peptide-based drug candidates to enhance metabolic stability, receptor selectivity, and bioavailability.
• Peptidomimetic Design: Used to create constrained or modified peptide structures for studying protein-protein interactions.
• Biochemical Probes: Synthesis of labeled or modified peptides for use in assay development and mechanistic studies.
• Academic & Contract Research: Fundamental research in medicinal chemistry, chemical biology, and structural biology.

Basic Information

Product Name	Fmoc-D-2-Me-Trp
CAS No.	196808-79-4
Molecular Formula	C₂₇H₂₄N₂O₄
Molecular Weight	440.49 g/mol
Synonyms	Fmoc-D-2-methyltryptophan; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-2-methyltryptophan; Fmoc-D-2-methyl-1H-indole-3-alanine; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(2-methyl-1H-indol-3-yl)propanoic acid; Fmoc-D-2-Me-Trp-OH; N-Fmoc-D-β-(2-methylindol-3-yl)alanine
EINECS	Contact for details

Quality Control

Our Fmoc-D-2-Me-Trp is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, essential for sensitive peptide synthesis applications. Each lot undergoes comprehensive analytical testing including HPLC for purity, chiral analysis to confirm stereochemical integrity, and identity confirmation via spectroscopic methods. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% de
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.