Description

Exendin-4 (3-39) is a synthetic peptide fragment derived from the naturally occurring hormone exendin-4, which is a glucagon-like peptide-1 (GLP-1) receptor agonist. This compound is a critical research tool for studying the structure-activity relationships of GLP-1 analogs and their metabolic effects. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on diabetes, obesity, and metabolic disorder therapeutics.

Application

• Pharmaceutical Research & Development: A key reference standard and intermediate in the development of novel GLP-1 receptor agonists for the treatment of type 2 diabetes and obesity.
• Biochemical Assay Development: Used to establish and validate in vitro binding and functional assays for screening potential drug candidates targeting the GLP-1 receptor.
• Structure-Activity Relationship (SAR) Studies: Essential for investigating the specific amino acid residues responsible for receptor binding affinity and biological activity of exendin-4 analogs.
• Academic & Preclinical Studies: Employed in university and institutional labs to explore the physiological roles of GLP-1 signaling pathways in metabolism and appetite regulation.
• Peptide Chemistry & Synthesis: Serves as a benchmark compound for optimizing solid-phase peptide synthesis (SPPS) and purification processes for complex peptides.
• Quality Control & Analytical Reference: Acts as a high-purity standard for HPLC, LC-MS, and other analytical methods to ensure the identity and purity of related peptide APIs.

Basic Information

Product Name	Exendin-4 (3-39)
CAS No.	196109-31-6
Molecular Formula	C184H282N50O60S
Molecular Weight	4186.6 g/mol
Synonyms	Exendin-4 (3-39), H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2; Exenatide (3-39); AC2993 (3-39); GLP-1 agonist fragment; Synthetic exendin-4 analog
EINECS	Contact for details

Quality Control

Our Exendin-4 (3-39) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research-grade specifications. Our quality commitment supports reliable and reproducible results for your critical projects.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass consistent with theoretical molecular weight
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.