Description

[Dpro5] Corticotropin Releasing Factor, Human, Rat is a synthetic peptide analog of the endogenous neuropeptide corticotropin-releasing factor (CRF). This compound is a critical research tool for studying the hypothalamic-pituitary-adrenal (HPA) axis, stress response, and related neurological disorders. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies engaged in neuroscience, endocrinology, and drug discovery programs.

Application

• Neuroscience Research: Used as a reference standard and agonist in studies investigating the physiological and behavioral effects of CRF receptor activation.
• Endocrinology Studies: Applied in vitro and in vivo to stimulate adrenocorticotropic hormone (ACTH) release from the pituitary gland, modeling the stress response.
• Drug Discovery & Screening: Serves as a key pharmacological tool for validating assays and screening potential CRF receptor antagonists for therapeutic development.
• Biochemical Analysis: Employed in receptor binding studies, signal transduction pathway analysis, and other mechanistic investigations.
• Animal Model Studies: Used to induce stress-like conditions in preclinical rodent models for research on anxiety, depression, and substance abuse.

Basic Information

Product Name	[Dpro5] Corticotropin Releasing Factor, Human, Rat
CAS No.	195628-97-8
Molecular Formula	C206H342N60O63S
Molecular Weight	4758.3 g/mol
Synonyms	[D-Pro5]-CRF (human, rat); [D-Pro5]-Corticotropin Releasing Factor; [D-Pro5]-Corticoliberin; [D-Pro5]h/rCRF; CRF, human, rat [D-Pro5]-; Dpro5-CRF; Corticotropin-Releasing Factor (5-41), human, rat, [D-Pro5]-; Sauvagine (5-40), [D-Pro5]-
EINECS	Contact for details

Quality Control

Our [Dpro5] Corticotropin Releasing Factor, Human, Rat is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and mass spectrometry for identity confirmation, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Solubility	Soluble in water, dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.