Description

Fmoc-L-Holys(Boc)-Oh CAS NO 194718-17-7 is a protected amino acid derivative, specifically an Fmoc-protected hydroxylysine building block with a tert-butyloxycarbonyl (Boc) group on the side-chain hydroxyl. This compound is a critical, high-purity intermediate designed for solid-phase peptide synthesis (SPPS), enabling the precise incorporation of modified lysine residues. It is essential for researchers and manufacturers in pharmaceutical development, particularly for creating complex peptides, bioconjugates, and investigating post-translational modifications like hydroxylation.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected building block for the automated synthesis of peptide chains.
• Pharmaceutical Research & Development: For the production of therapeutic peptides targeting various diseases.
• Bioconjugation and Probe Development: Utilized to introduce a uniquely protected amino group for site-specific labeling or linker attachment.
• Collagen-Mimetic Peptide Synthesis: Critical for incorporating hydroxylysine, a crucial component of collagen and related structural proteins.
• Glycopeptide Synthesis: Serves as a precursor for the synthesis of peptides containing glycosylated hydroxylysine residues.
• Chemical Biology Studies: Used to probe protein-protein interactions and enzyme function involving hydroxylated amino acids.
• Process Development for API Manufacturing: Serves as a high-quality raw material in the scaled-up production of peptide-based active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Fmoc-L-Holys(Boc)-Oh
CAS No.	194718-17-7
Molecular Formula	C31H40N2O8
Molecular Weight	568.66 g/mol
Synonyms	Fmoc-Hyl(Boc)-OH; N-α-Fmoc-N-ε-Boc-L-hydroxylysine; Fmoc-L-hydroxylysine(Boc)-OH; (2S,5R)-5-{[(tert-Butoxy)carbonyl]amino}-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid; Fmoc-Lys(Boc,OH)-OH; Fmoc-L-Hydroxylysine(Boc)-OH; Nα-Fmoc-Nε-Boc-L-hydroxylysine; Fmoc-Hyl(Boc)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-L-Holys(Boc)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and cGMP manufacturing. Each lot undergoes comprehensive analytical testing including HPLC for purity, chiral analysis, and identity confirmation. A detailed Certificate of Analysis (COA) is provided, documenting compliance with stringent in-house specifications. We support our clients' regulatory needs with full traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach ambient temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Purity (HPLC)	≥98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.