Description

Fmoc-3-Amino-4,4,4-Trifluorobutyric Acid is a high-purity, non-natural amino acid derivative featuring a trifluoromethyl group, which is critical for modulating the physicochemical properties of peptides and small molecules. This compound serves as a versatile Fmoc-protected building block for solid-phase peptide synthesis (SPPS), enabling the precise incorporation of fluorine to enhance metabolic stability, lipophilicity, and binding affinity. It is primarily utilized by pharmaceutical researchers and fine chemical manufacturers engaged in the development of peptide-based therapeutics, diagnostic agents, and advanced materials.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the automated synthesis of fluorinated peptides.
• Pharmaceutical Research: Building block for developing peptide drugs with improved bioavailability and target selectivity.
• Chemical Biology Probes: Used to create fluorinated peptide probes for studying protein-protein interactions and enzyme activity.
• PET (Positron Emission Tomography) Tracer Development: Serves as a precursor for synthesizing fluorine-18 labeled compounds for diagnostic imaging.
• Material Science: Incorporation into specialty polymers and coatings to impart unique surface properties.
• Agrochemical Research: Intermediate in the synthesis of novel bioactive compounds with enhanced stability.

Basic Information

Product Name	Fmoc-3-Amino-4,4,4-Trifluorobutyric Acid
CAS No.	194471-86-8
Molecular Formula	C19H16F3NO4
Molecular Weight	379.33 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-amino-4,4,4-trifluorobutanoic acid; Fmoc-3-Amino-4,4,4-trifluorobutanoic Acid; 3-[(Fmoc-amino]-4,4,4-trifluorobutyric acid; 4,4,4-Trifluoro-3-[(9-fluorenylmethoxycarbonyl)amino]butyric acid; Fmoc-D,L-3-Amino-4,4,4-trifluorobutyric Acid; Fmoc-3-ATFBA; (RS)-3-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-4,4,4-trifluorobutanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-3-Amino-4,4,4-Trifluorobutyric Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with exacting standards for peptide synthesis. Certificates of Analysis (COA) detailing purity, chiral purity (if applicable), and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach ambient temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	Contact for details
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.