Description

Fmoc-L-β-Homoisoleucine CAS NO 193954-27-7 is a high-purity, non-proteinogenic amino acid derivative specifically engineered for advanced peptide synthesis. This compound matters as a critical building block for introducing the unique steric and hydrophobic properties of the β-homoisoleucine side chain under Fmoc-protection strategies, enabling the creation of novel peptides with enhanced stability and biological activity. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of peptide-based therapeutics, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/t-Bu strategy, facilitating the automated synthesis of complex peptides.
• Pharmaceutical Research: Used in the R&D of novel peptide drugs, hormones, and enzyme inhibitors where modified amino acids are required for metabolic stability or receptor binding.
• Peptidomimetics Design: Incorporation into peptide analogs to study structure-activity relationships (SAR) and improve pharmacological profiles.
• Bioconjugation: Serves as a specialized linker or component in the synthesis of peptide-antibody conjugates or other bioconjugates for targeted therapies.
• Chemical Biology Probes: Utilized in the synthesis of labeled or tagged peptides for use in cellular imaging, proteomics, and mechanistic studies.
• Academic & Industrial R&D: Fundamental research tool in universities and biotech companies for exploring protein folding, peptide libraries, and new synthetic methodologies.

Basic Information

Product Name	Fmoc-L-β-Homoisoleucine
CAS No.	193954-27-7
Molecular Formula	C25H29NO5
Molecular Weight	423.50 g/mol
Synonyms	Fmoc-β-hIle-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-β-homoisoleucine; Fmoc-L-β-Homo-Ile; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-4-methyl-3-propylpentanoic acid; Fmoc-(S)-2-amino-4-methyl-3-propylpentanoic acid; N-Fmoc-L-β-homoisoleucine; Fmoc-L-β-Homoisoleucine; Fmoc-β-Homo-Ile-OH
EINECS	Contact for details

Quality Control

Our Fmoc-L-β-Homoisoleucine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, and is supplied with a corresponding Certificate of Analysis (COA). We adhere to industry best practices, and specifications can be aligned with customer-specific requirements for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed in a desiccated environment and handled under conditions that minimize exposure to ambient light and humidity to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.