Description

Fmoc-L-β-Homoalanine CAS NO 193954-26-6 is a high-purity, non-natural amino acid derivative specifically engineered for advanced peptide synthesis. This compound is critical for introducing structural modifications and enhancing the stability or biological activity of synthetic peptides. It is an essential building block for pharmaceutical research, particularly in the development of novel therapeutics, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/t-Bu strategy, enabling the controlled assembly of complex peptide sequences.
• Pharmaceutical R&D: Used to synthesize peptide-based drug candidates, including hormone analogs, enzyme inhibitors, and targeted delivery vectors.
• Peptidomimetics Design: Incorporates a β-homoalanine backbone, a homolog of alanine, to create peptides with altered conformational properties and enhanced metabolic stability.
• Bioconjugation & Labeling: Serves as a versatile intermediate for attaching fluorophores, biotin, or other functional groups to peptides for imaging and detection studies.
• Combinatorial Chemistry: A valuable component in libraries for high-throughput screening to discover new bioactive molecules.
• Academic & Institutional Research: Fundamental reagent for studying protein structure-function relationships and peptide biochemistry.

Basic Information

Product Name	Fmoc-L-β-Homoalanine
CAS No.	193954-26-6
Molecular Formula	C20H21NO4
Molecular Weight	339.39 g/mol
Synonyms	Fmoc-βhAla-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-amino-butanoic acid; Fmoc-L-β-Homoalanine; Fmoc-(S)-3-Aminobutanoic Acid; N-Fmoc-L-β-Homoalanine; (S)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)butanoic acid; Fmoc-L-3-Aminobutanoic Acid; N-α-Fmoc-L-β-homoalanine
EINECS	Contact for details

Quality Control

Our Fmoc-L-β-Homoalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via NMR and mass spectrometry. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.