Description

(S)-Fmoc-Beta2-Homoleucine CAS NO 193887-45-5 is a high-purity, non-natural amino acid derivative specifically engineered for advanced peptide synthesis. This compound is a critical building block in the development of novel peptide-based pharmaceuticals and research tools, offering precise stereochemical control. It is primarily utilized by medicinal chemists and research scientists in pharmaceutical R&D, biotechnology, and academic institutions focused on drug discovery and peptide engineering.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/t-Bu strategy, enabling the controlled assembly of complex peptides.
• Peptidomimetic Drug Development: Used to incorporate the beta2-homoleucine side chain into peptide backbones, enhancing metabolic stability and bioavailability of therapeutic candidates.
• Structure-Activity Relationship (SAR) Studies: Essential for probing the role of specific side-chain length and hydrophobicity in peptide-receptor interactions.
• Synthesis of Biologically Active Peptides: Facilitates the production of peptides for use in biochemical assays, target validation, and as reference standards.
• Combinatorial Chemistry Libraries: Serves as a valuable component for creating diverse peptide libraries to screen for new biological activity.
• Academic and Industrial Research: A fundamental reagent for investigating protein folding, peptide self-assembly, and novel biomaterials.

Basic Information

Product Name	(S)-Fmoc-Beta2-Homoleucine
CAS No.	193887-45-5
Molecular Formula	C22H25NO4
Molecular Weight	367.44 g/mol
Synonyms	(S)-2-(((9H-Fluoren-9-yl)methoxy)carbonylamino)-4-methylhexanoic acid; Fmoc-β2-hLeu-OH; Fmoc-β-Homoleucine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-β2-homoleucine; (S)-N-Fmoc-3-amino-5-methylhexanoic acid; Fmoc-β2-Hle-OH; (S)-Fmoc-β2-homoleucine
EINECS	Contact for details

Quality Control

Our (S)-Fmoc-Beta2-Homoleucine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to industry best practices, and specifications can be aligned with customer-specific requirements for advanced pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.