Description

(3S)-Fmoc-1-Pyrrolidine-3-Carboxylic Acid CAS NO 193693-66-2 is a high-purity, non-natural amino acid derivative featuring a 9-fluorenylmethoxycarbonyl (Fmoc) protecting group on the pyrrolidine nitrogen. This compound is a critical chiral building block in modern solid-phase peptide synthesis (SPPS), enabling the controlled introduction of the (S)-pyrrolidine-3-carboxylic acid moiety into complex peptide sequences. It is essential for research and development laboratories in the pharmaceutical and biotechnology sectors focused on creating novel peptide-based therapeutics, diagnostics, and chemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated synthesis of therapeutic peptides.
• Pharmaceutical Intermediates: Serves as a chiral precursor in the synthesis of active pharmaceutical ingredients (APIs) with proline-like structures.
• Peptidomimetic Research: Used to incorporate constrained pyrrolidine rings into peptide backbones to enhance metabolic stability and bioavailability.
• Chemical Biology: Employed in the synthesis of labeled peptides for proteomics studies and target identification.
• Libraries for Drug Discovery: A valuable component for generating combinatorial peptide libraries used in high-throughput screening.
• Agrochemical Research: Potential use in the development of novel bioactive compounds with peptide motifs.

Basic Information

Product Name	(3S)-Fmoc-1-Pyrrolidine-3-Carboxylic Acid
CAS No.	193693-66-2
Molecular Formula	C₂₀H₁₉NO₄
Molecular Weight	337.37 g/mol
Synonyms	Fmoc-3S-Pyrrolidine-3-Carboxylic Acid; (S)-1-((((9H-Fluoren-9-yl)methoxy)carbonyl)pyrrolidine-3-carboxylic acid; 1-Fmoc-(3S)-pyrrolidine-3-carboxylic acid; Fmoc-L-HomoPro-OH; Fmoc-L-3,4-dehydroproline (reduced form analog); N-α-Fmoc-3S-pyrrolidinecarboxylic acid; N-Fmoc-3(S)-pyrrolidinecarboxylic acid; (S)-1-Fmoc-pyrrolidine-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our (3S)-Fmoc-1-Pyrrolidine-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for peptide synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, chiral excess, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is light-sensitive (store away from light). For long-term storage, consider storing desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.