Description

(R)-1-Fmoc-3-Pyrrolidinecarboxylic Acid is a high-purity, chiral building block essential for modern organic synthesis. This compound is a critical intermediate in the production of complex molecules, offering precise stereochemical control for advanced research and development. It is primarily utilized by pharmaceutical, biotechnology, and fine chemical industries for applications in peptide synthesis, medicinal chemistry, and the development of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the asymmetric synthesis of drug candidates and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used as a protected amino acid derivative in solid-phase and solution-phase peptide synthesis, particularly for introducing proline analogs.
• Medicinal Chemistry & Drug Discovery: Serves as a versatile building block for constructing compound libraries and exploring structure-activity relationships (SAR).
• Bioconjugation: Employed in the synthesis of peptide-based linkers and probes for bioconjugation and labeling applications.
• Catalyst & Ligand Development: Acts as a precursor for chiral catalysts and ligands used in asymmetric catalysis.
• Academic & Industrial R&D: Essential for research in organic chemistry, chemical biology, and material science requiring high-fidelity chiral centers.

Basic Information

Product Name	(R)-1-Fmoc-3-Pyrrolidinecarboxylic Acid
CAS No.	193693-65-1
Molecular Formula	C₂₀H₁₉NO₄
Molecular Weight	337.37 g/mol
Synonyms	(R)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-pyrrolidinecarboxylic Acid; (R)-1-Fmoc-pyrrolidine-3-carboxylic Acid; Fmoc-D-Pro-OH(3); (R)-N-Fmoc-3-pyrrolidinecarboxylic Acid; (3R)-1-(9H-Fluoren-9-ylmethoxycarbonyl)pyrrolidine-3-carboxylic Acid; (R)-1-(9-Fluorenylmethoxycarbonyl)pyrrolidine-3-carboxylic Acid; (R)-Fmoc-Pro(3)-OH; (R)-N-[(9H-Fluoren-9-ylmethoxy)carbonyl]pyrrolidine-3-carboxylic Acid
EINECS	Contact for details

Quality Control

Our (R)-1-Fmoc-3-Pyrrolidinecarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.