Description

Fmoc-L-Azetidine-3-Carboxylic Acid CAS NO 193693-64-0 is a high-purity, protected amino acid derivative essential for advanced peptide synthesis. This compound serves as a critical building block for introducing the conformationally constrained azetidine ring into peptide chains, enabling the development of novel bioactive molecules with enhanced stability and potency. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, medicinal chemistry, and the development of peptide-based therapeutics and diagnostics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key monomer for the Fmoc-strategy synthesis of complex peptides containing the azetidine scaffold.
• Medicinal Chemistry & Drug Discovery: Used to create constrained peptide analogs and peptidomimetics for screening against biological targets.
• Bioconjugation: Serves as a specialized linker or spacer molecule for attaching peptides to other biomolecules, surfaces, or reporter groups.
• Chemical Biology Research: Employed in the study of protein-protein interactions and enzyme mechanisms by incorporating non-natural amino acids.
• API Intermediate Development: Acts as a crucial intermediate in the synthetic pathway of active pharmaceutical ingredients (APIs) with peptide backbones.
• Library Synthesis: Used in combinatorial chemistry to generate diverse libraries of azetidine-containing compounds for high-throughput screening.

Basic Information

Product Name	Fmoc-L-Azetidine-3-Carboxylic Acid
CAS No.	193693-64-0
Molecular Formula	C19H17NO4
Molecular Weight	323.34 g/mol
Synonyms	(S)-1-((((9H-Fluoren-9-yl)methoxy)carbonyl)azetidine-3-carboxylic acid; Fmoc-Aze-OH; Fmoc-L-Aze-OH; N-α-Fmoc-L-azetidine-3-carboxylic acid; Fmoc-3-carboxyazetidine; 1-Fmoc-azetidine-3-carboxylic acid; (S)-1-(9-Fluorenylmethoxycarbonyl)azetidine-3-carboxylic acid; N-Fmoc-azetidine-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our Fmoc-L-Azetidine-3-Carboxylic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment. For long-term storage, consider desiccants and an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.