Description

Fmoc-L-β-Homoproline CAS NO 193693-60-6 is a high-purity, protected amino acid derivative essential for modern solid-phase peptide synthesis (SPPS). This compound serves as a critical building block for introducing the unique conformational constraints of the homoproline scaffold into complex peptide sequences, enabling the development of novel bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, proteomics research, and the development of peptide-based therapeutics and diagnostics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected amino acid for the automated synthesis of custom peptides.
• Drug Discovery & Medicinal Chemistry: Used to incorporate homoproline motifs into peptide libraries for screening against biological targets.
• Peptidomimetic Development: Essential for creating modified peptides with enhanced stability, bioavailability, or receptor affinity.
• Bioconjugation & Probe Synthesis: Serves as a precursor for labeling peptides with fluorescent tags or other reporter molecules.
• Academic & Industrial Research: Employed in studying protein-protein interactions, enzyme substrates, and structural biology.
• API Intermediate: Potential use as an intermediate in the synthesis of active pharmaceutical ingredients (APIs) for peptide drugs.

Basic Information

Product Name	Fmoc-L-β-Homoproline
CAS No.	193693-60-6
Molecular Formula	C₂₁H₂₁NO₄
Molecular Weight	351.40 g/mol
Synonyms	Fmoc-β-Hopro-OH; Fmoc-L-β-Homoproline; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-β-homoproline; (S)-1-((((9H-Fluoren-9-yl)methoxy)carbonyl)-2,3,4,5-tetrahydro-1H-azepine-2-carboxylic acid; Fmoc-β-Hpr-OH; N-α-Fmoc-L-β-homoproline; Fmoc-L-β-Hpr-OH; Fmoc-β-homoPro-OH
EINECS	Contact for details

Quality Control

Our Fmoc-L-β-Homoproline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the high standards required for sensitive peptide synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability, consistency, and compliance with research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.