Description

2-(Fmoc-Amino)-4-Pentynoic Acid is a high-purity, protected amino acid derivative featuring an alkyne functional group, making it a critical building block for advanced organic synthesis. Its core value lies in enabling precise, site-specific bioconjugation and the construction of complex peptide-based architectures through click chemistry and solid-phase peptide synthesis (SPPS). This compound is essential for researchers and manufacturers in pharmaceutical development, proteomics, and chemical biology who require reliable, high-quality intermediates for drug discovery and biomolecule labeling.

Application

• Peptide Synthesis: A key Fmoc-protected amino acid building block for the solid-phase synthesis of peptides containing non-natural, alkyne-functionalized side chains.
• Bioconjugation & Labeling: Enables site-specific modification of peptides, proteins, and other biomolecules via copper-catalyzed azide-alkyne cycloaddition (CuAAC) or strain-promoted click chemistry.
• Chemical Probe Development: Used to create activity-based probes and affinity tags for studying enzyme function and protein-protein interactions in complex biological systems.
• Drug Discovery: Serves as a versatile intermediate in the synthesis of peptide-drug conjugates (PDCs) and other targeted therapeutic agents.
• Material Science: Incorporation into polymers and surfaces to create functionalized materials with specific biological recognition properties.
• Library Synthesis: A valuable reagent for generating diverse combinatorial libraries of alkyne-containing compounds for high-throughput screening.

Basic Information

Product Name	2-(Fmoc-Amino)-4-Pentynoic Acid
CAS No.	191215-87-9
Molecular Formula	C₂₀H₁₇NO₄
Molecular Weight	335.35 g/mol
Synonyms	Fmoc-4-pentynoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-pentynoic acid; 4-Pentynoic acid, 2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-; Fmoc-L-homopropargylglycine; Fmoc-Hpg-OH; N-α-Fmoc-L-2-amino-4-pentynoic acid; 2-(Fmoc-amino)pent-4-ynoic acid; N-Fmoc-2-amino-4-pentynoic acid
EINECS	Contact for details

Quality Control

Our 2-(Fmoc-Amino)-4-Pentynoic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and MS for identity verification, to ensure it meets the exacting standards required for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed specifications are provided to guarantee traceability, consistency, and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.