Description

(Lys15)-Amyloid β-Protein (15-21) CAS NO 190775-14-5 is a specific, high-purity synthetic peptide fragment derived from the amyloid β-protein sequence, a key target in neurodegenerative disease research. This compound is critical for studying the molecular mechanisms of amyloid aggregation, fibril formation, and neurotoxicity, providing researchers with a precise tool for biochemical and biophysical assays. It is primarily utilized by pharmaceutical R&D teams, academic research laboratories, and biotechnology companies focused on Alzheimer's disease and related therapeutic development.

Application

• Biochemical Research: Fundamental studies on amyloid β-protein structure, folding, and aggregation kinetics.
• Drug Discovery Screening: Used as a target substrate in high-throughput screening (HTS) assays to identify potential inhibitors of amyloid aggregation.
• Antibody & Diagnostic Development: Serves as an antigen for the production and characterization of antibodies specific to the amyloid beta epitope.
• Biophysical Analysis: Employed in techniques such as circular dichroism (CD), nuclear magnetic resonance (NMR), and surface plasmon resonance (SPR) to study peptide interactions.
• Toxicity Studies: Used in cell-based models to assess the neurotoxic effects of specific amyloid beta fragments.
• Reference Standard: Acts as a certified reference material (CRM) for quality control in assay development and validation.

Basic Information

Product Name	(Lys15)-Amyloid β-Protein (15-21)
CAS No.	190775-14-5
Molecular Formula	C38H62N12O11
Molecular Weight	862.98 g/mol
Synonyms	Amyloid β-Protein (15-21) (Lys15); Aβ(15-21) (Lys15); H-Lys-Leu-Val-Phe-Phe-Ala-Glu-OH; KLVFFAE; Lysine-modified Amyloid Beta (15-21) fragment; Amyloid Beta Peptide (15-21) with Lysine substitution; KLVFFAE peptide; Aβ15-21 (Lys15)
EINECS	Contact for details

Quality Control

Every batch of (Lys15)-Amyloid β-Protein (15-21) is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. Our products are supplied with a detailed Certificate of Analysis (COA) that includes data for purity (HPLC), peptide content, amino acid analysis, and mass spectrometry (MS) confirmation. We ensure compliance with the stringent requirements for research-grade peptides, supporting reproducible and reliable scientific outcomes.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This hygroscopic and moisture-sensitive material should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. Aliquot into single-use vials to minimize freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by amino acid analysis)
Molecular Weight	862.98 ± 1.0 Da (by MS)
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water or aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.