Description

(8α,9R)-(8''α,9''R)-9,9''-[(2,5-Diphenyl-4,6-Pyrimidinediyl)Bis(Oxy)]Bis[6'-Methoxy-Cinchonan is a sophisticated, high-purity chiral compound derived from cinchona alkaloid chemistry, serving as a critical advanced intermediate or chiral ligand in asymmetric synthesis. Its value lies in enabling precise stereochemical control for the production of enantiomerically pure pharmaceuticals and fine chemicals. This product is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require high-fidelity building blocks for complex molecular architectures.

Application

• Asymmetric Catalysis: Employed as a chiral ligand or catalyst precursor in transition metal-catalyzed reactions, such as asymmetric hydrogenation, dihydroxylation, or epoxidation.
• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs) targeting central nervous system, cardiovascular, or anti-infective therapies.
• Chiral Resolution Agent: Used in the development of chiral stationary phases for analytical or preparative chromatography to separate enantiomers.
• Agrochemical Synthesis: Applied in the research and production of chiral pesticides and herbicides where specific stereochemistry is required for bioactivity.
• Academic & Industrial R&D: A valuable tool for methodological development in organic synthesis and catalysis within university and corporate research laboratories.
• Fine Chemical Production: Integral to the manufacture of high-value, complex fragrance, flavor, or electronic chemical intermediates.

Basic Information

Product Name	(8α,9R)-(8''α,9''R)-9,9''-[(2,5-Diphenyl-4,6-Pyrimidinediyl)Bis(Oxy)]Bis[6'-Methoxy-Cinchonan
CAS No.	189745-70-8
Molecular Formula	C52H52N4O6
Molecular Weight	828.99 g/mol
Synonyms	9,9'-[(2,5-Diphenyl-4,6-pyrimidinediyl)bis(oxy)]bis[6'-methoxycinchonan]; Cinchonan, 9,9'-[(2,5-diphenyl-4,6-pyrimidinediyl)bis(oxy)]bis[6'-methoxy-; (8α,9R)-9,9'-[(2,5-Diphenyl-4,6-pyrimidinediyl)bis(oxy)]bis[6'-methoxycinchonan]; (8α,9R)-(8'α,9'R)-9,9'-[(2,5-Diphenyl-4,6-pyrimidinediyl)bis(oxy)]bis[6'-methoxycinchonan]; DPMOC Ligand (contextual); Chiral Bis-Cinchona Alkaloid Derivative; Contact for additional trade names.
EINECS	Contact for details

Quality Control

Our production of (8α,9R)-(8''α,9''R)-9,9''-[(2,5-Diphenyl-4,6-Pyrimidinediyl)Bis(Oxy)]Bis[6'-Methoxy-Cinchonan adheres to stringent GMP and ISO 9001 guidelines to ensure batch-to-batch consistency and traceability. Each lot undergoes comprehensive analytical characterization, including HPLC for chiral purity and assay, NMR for structural confirmation, and MS for identity verification. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider using desiccants or storing under an inert atmosphere to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.