Description

Fadolmidine Hydrochloride is a high-purity, non-narcotic α-2 adrenergic receptor agonist. This compound is of significant interest for its potential therapeutic applications, particularly in the field of analgesia and neuropharmacology. It is primarily utilized by pharmaceutical research and development organizations, contract research organizations (CROs), and fine chemical manufacturers engaged in the synthesis of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Research & Development: A key intermediate or reference standard in the development of novel analgesic and neuroprotective drugs.
• Preclinical Studies: Used in animal model research to investigate mechanisms of pain modulation and the role of α-2 adrenergic receptors.
• Chemical Synthesis: Serves as a critical building block for medicinal chemists synthesizing new chemical entities (NCEs) with targeted receptor activity.
• Analytical Reference Standard: Employed in HPLC, LC-MS, and NMR for method development, validation, and quality control of related substances.
• Biochemical Assays: Used as a ligand in receptor binding studies and functional assays to characterize pharmacological profiles.

Basic Information

Product Name	Fadolmidine Hydrochloride
CAS No.	189353-32-0
Molecular Formula	C13H16N2•HCl
Molecular Weight	236.74 g/mol
Synonyms	Fadolmidine HCl; (S)-2-[(4,5-Dihydro-1H-imidazol-2-yl)methyl]-2,3-dihydro-1-methyl-1H-indene Hydrochloride; (S)-2-(2-Imidazolin-2-ylmethyl)-1-methylindane Hydrochloride; MPV-2426; MPV 2426; Dexmedetomidine analogue; α-2 adrenoceptor agonist
EINECS	Contact for details

Quality Control

Our Fadolmidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral purity determination, and identification by spectroscopic methods, to ensure it meets the stringent requirements for research and development use. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.