Description

(R)-2,2,2-Trifluoro-1-Phenylethylamine Hcl CAS NO 189350-64-9 is a high-purity chiral amine building block, specifically the hydrochloride salt of the (R)-enantiomer. This compound is a critical intermediate in the synthesis of advanced pharmaceuticals and agrochemicals, where its trifluoromethyl group and chiral center impart unique biological activity and metabolic stability. It is primarily required by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for creating novel active ingredients and complex molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) drugs and enzyme inhibitors.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides that leverage the stability of the trifluoromethyl group.
• Asymmetric Catalysis: Serves as a chiral ligand precursor or auxiliary in asymmetric synthesis to induce enantioselectivity.
• Peptidomimetics & Bioactive Molecules: Incorporated into the backbone of peptide analogs and other bioactive compounds to enhance binding affinity and pharmacokinetic properties.
• Material Science Research: Employed in the synthesis of specialty polymers and advanced organic materials with specific optical or electronic characteristics.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	(R)-2,2,2-Trifluoro-1-Phenylethylamine Hydrochloride
CAS No.	189350-64-9
Molecular Formula	C8H9ClF3N
Molecular Weight	211.61 g/mol
Synonyms	(R)-α-(Trifluoromethyl)benzylamine Hydrochloride; (R)-1-Phenyl-2,2,2-trifluoroethylamine HCl; (R)-TFM Benzylic Amine HCl; (R)-1-Phenylethylamine, 2,2,2-trifluoro-, hydrochloride; (R)-2,2,2-Trifluoro-1-phenylethanamine hydrochloride; (R)-1-(Trifluoromethyl)phenethylamine HCl; (R)-F3C-Benzylamine HCl
EINECS	Contact for details

Quality Control

Our (R)-2,2,2-Trifluoro-1-Phenylethylamine HCl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.