Description

Fmoc-Thr(Tbu)-Ol CAS NO 189337-28-8 is a protected amino acid derivative, specifically an Fmoc-protected threonine tert-butyl ether, designed for use in solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring high-purity, orthogonally protected building blocks to construct complex peptides with precise sequence control. It is an essential raw material for pharmaceutical R&D, biotechnology, and academic laboratories focused on developing novel peptide-based therapeutics, diagnostics, and research tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key building block for the automated, stepwise assembly of peptide chains on resin.
• Pharmaceutical Intermediate: For the research and development of peptide drugs, including hormones, antibiotics, and enzyme inhibitors.
• Bioconjugation: Used to introduce threonine residues with orthogonal protection for subsequent labeling or coupling reactions.
• Combinatorial Chemistry: A valuable component in libraries for drug discovery and screening.
• Academic & Institutional Research: For studying protein structure-function relationships, enzyme mechanisms, and signal transduction pathways.
• Production of Custom Peptides: By CROs (Contract Research Organizations) and CDMOs (Contract Development and Manufacturing Organizations) for client projects.

Basic Information

Product Name	Fmoc-Thr(Tbu)-Ol
CAS No.	189337-28-8
Molecular Formula	C23H27NO5
Molecular Weight	397.47 g/mol
Synonyms	Fmoc-Thr(tBu)-ol; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-(tert-butyl)-L-threoninol; Fmoc-O-tert-butyl-L-threoninol; L-Threoninol, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-(1,1-dimethylethyl)-; Fmoc-L-threoninol(tBu); N-Fmoc-O-tert-butylthreoninol; (2S,3R)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-((tert-butoxy)methyl)-3-hydroxybutan-1-ol
EINECS	Contact for details

Quality Control

Our Fmoc-Thr(Tbu)-Ol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for sensitive synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.