Description

Amyloid Precursor Frameshift Mutant C-Terminal Peptide Trifluoroacetate Salt H-Arg-Gly-Arg-Thr-Ser-Ser-Lys-Glu-Leu-Ala-Oh Trifluoroacetate Salt is a synthetic peptide sequence corresponding to a specific C-terminal fragment of the amyloid precursor protein (APP) containing a frameshift mutation. This compound is a critical research tool for investigating the molecular mechanisms underlying Alzheimer's disease and related neurodegenerative disorders. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on neurobiology and drug discovery.

Application

• Biochemical Research: Used as a key substrate or reference standard in studies of APP processing, amyloid-beta (Aβ) peptide generation, and the pathological effects of frameshift mutations.
• Drug Discovery & Screening: Serves as a target molecule in high-throughput screening (HTS) assays to identify potential inhibitors of abnormal APP cleavage or aggregation.
• Antibody Development & Validation: Acts as an immunogen for generating antibodies specific to mutant APP fragments or as a coating antigen in ELISA and other immunoassays.
• Mechanistic Studies: Employed in cell-based and in vitro models to elucidate the role of specific C-terminal APP fragments in cellular signaling, toxicity, and disease progression.
• Proteomics & Mass Spectrometry: Functions as a calibrated standard for the identification and quantification of APP-derived peptides in complex biological samples.
• Quality Control Reference: Provides a benchmark for the purity and activity of related peptide-based reagents and diagnostic kits.

Basic Information

Product Name	Amyloid Precursor Frameshift Mutant C-Terminal Peptide Trifluoroacetate Salt H-Arg-Gly-Arg-Thr-Ser-Ser-Lys-Glu-Leu-Ala-Oh Trifluoroacetate Salt
CAS No.	189125-14-2
Molecular Formula	C48H86N20O16 • xC2HF3O2
Molecular Weight	1183.3 g/mol (Free base)
Synonyms	APP Frameshift Mutant C-Terminal Fragment; H-Arg-Gly-Arg-Thr-Ser-Ser-Lys-Glu-Leu-Ala-OH TFA salt; APP (672-681) frameshift mutant; H-RGRTSSKELA-OH TFA salt; Amyloid Beta A4 Protein Fragment (672-681) frameshift analog; C-Terminal APP Peptide (mutant); CAS 189125-14-2
EINECS	Contact for details

Quality Control

Our peptide products are manufactured and analyzed under strict quality management systems. Each batch of Amyloid Precursor Frameshift Mutant C-Terminal Peptide Trifluoroacetate Salt undergoes rigorous analytical testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing comprehensive specifications, including HPLC purity, amino acid analysis, and mass spectrometry data, are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Amino Acid Composition	Within ±10% of theoretical values
Peptide Content	≥ 70% (by weight)
Water Content (KF)	≤ 8.0%
Trifluoroacetate Content	≤ 15.0% (by HPLC)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.