Description

(Ala92)-P16 (84-103) CAS NO 189064-08-2 is a synthetic peptide fragment derived from the P16 protein sequence, specifically encompassing amino acids 84 to 103 with an alanine substitution at position 92. This high-purity peptide is critical for advanced biochemical research and pharmaceutical development, offering a defined molecular tool for studying protein-protein interactions, cellular signaling pathways, and oncogenic mechanisms. It is primarily utilized by research institutions, biotechnology companies, and pharmaceutical developers focused on cancer biology, immunology, and therapeutic peptide discovery.

Application

• Biochemical Research: Used as a standard or probe in studies investigating the structure and function of the P16 tumor suppressor protein and its role in the cell cycle.
• Antigen Production: Serves as a hapten for generating specific antibodies against the P16 protein for use in immunoassays like ELISA and Western Blot.
• Cell Signaling Studies: Applied in vitro to analyze interactions with binding partners such as CDK4 and CDK6, helping to elucidate mechanisms of cellular senescence and carcinogenesis.
• Drug Discovery Screening: Acts as a target molecule in high-throughput screening assays to identify potential inhibitors or modulators of P16-related pathways.
• Diagnostic Development: Employed in the development and calibration of diagnostic kits for detecting P16 expression or mutations in clinical samples.
• Academic & Pharmaceutical R&D: Provides a key reagent for basic science and pre-clinical research aimed at understanding cancer biology and developing novel oncology therapeutics.

Basic Information

Product Name	(Ala92)-P16 (84-103)
CAS No.	189064-08-2
Molecular Formula	C98H155N29O28S
Molecular Weight	~2230.5 g/mol
Synonyms	P16 (84-103) (Ala92) analog; Cyclin-dependent kinase inhibitor 2A fragment 84-103 (Ala92); INK4a (84-103) Ala92 variant; CDKN2A (84-103) peptide analog; p16INK4a (84-103) alanine mutant; Tumor suppressor p16 fragment; MTS-1 peptide fragment; 9p21-encoded protein fragment
EINECS	Contact for details

Quality Control

Every batch of (Ala92)-P16 (84-103) is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality commitment includes comprehensive characterization by HPLC, MS (Mass Spectrometry), and amino acid analysis. Certificates of Analysis (COA) detailing purity, peptide content, and solvent residues are available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to keep the lyophilized powder desiccated. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Composition	Within ±10% of theoretical
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.