Description

2-Morpholino-4,6-difluoropyrimidine is a high-purity, specialized heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in its bifunctional reactivity, featuring both a morpholine ring and difluoropyrimidine scaffold, which makes it a versatile precursor for constructing complex molecular architectures. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients, particularly kinase inhibitors and other biologically relevant molecules.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of potential drug candidates, especially for targeted therapies.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides with enhanced properties.
• Chemical Biology & Proteomics: Serves as a valuable scaffold for designing chemical probes and enzyme inhibitors.
• Material Science Research: Employed in the synthesis of advanced organic materials and ligands for catalysis.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring specific fluorinated heterocycles.
• Academic & Industrial R&D: Fundamental building block for methodological studies and exploring new chemical spaces in heterocyclic chemistry.

Basic Information

Product Name	2-Morpholino-4,6-difluoropyrimidine
CAS No.	189003-02-9
Molecular Formula	C8H9F2N3O
Molecular Weight	201.18 g/mol
Synonyms	4,6-Difluoro-2-morpholinopyrimidine; 2-(4-Morpholinyl)-4,6-difluoropyrimidine; 4,6-Difluoro-2-morpholino-1,3-diazine; 189003-02-9; 2-Morpholino-4,6-difluoro-1,3-diazine; 4,6-Difluoro-2-(morpholin-4-yl)pyrimidine; 2-(Morpholin-4-yl)-4,6-difluoropyrimidine
EINECS	Contact for details

Quality Control

Our 2-Morpholino-4,6-difluoropyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.