Description

3-n-Fmoc-3-(4-Fluorophenyl)Propionic Acid is a high-purity, fluorinated building block designed for advanced organic synthesis. This compound is critical for researchers and manufacturers requiring precise molecular architecture, particularly in the development of complex bioactive molecules. It is primarily utilized in the pharmaceutical and biotechnology sectors for peptide synthesis and medicinal chemistry applications, where its Fmoc-protected carboxylic acid group and fluorinated aromatic ring offer valuable synthetic handles.

Application

• Pharmaceutical Intermediates: A key building block in the synthesis of novel Active Pharmaceutical Ingredients (APIs) and drug candidates.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis as a protected amino acid derivative, enabling the construction of complex peptide sequences.
• Medicinal Chemistry & Drug Discovery: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in high-throughput screening.
• Bioconjugation: Facilitates the site-specific labeling and modification of biomolecules, such as proteins and antibodies, for diagnostic and therapeutic applications.
• Chemical Biology Probes: Employed in the development of fluorescent or affinity probes to study biological pathways and protein function.
• Material Science Research: Acts as a monomer or precursor for specialized polymers and advanced organic materials with tailored properties.

Basic Information

Product Name	3-n-Fmoc-3-(4-Fluorophenyl)Propionic Acid
CAS No.	188814-36-0
Molecular Formula	C24H19FO4
Molecular Weight	390.41 g/mol
Synonyms	3-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(4-fluorophenyl)propanoic acid; N-Fmoc-3-(4-fluorophenyl)-β-alanine; Fmoc-4-F-β-homoPhe-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(4-fluorophenyl)-β-alanine; 3-(4-Fluorophenyl)-3-[(9H-fluoren-9-ylmethoxy)formamido]propanoic acid; Fmoc-3-(4-fluorophenyl)-β-alanine; 3-(Fmoc-amino)-3-(4-fluorophenyl)propionic acid
EINECS	Contact for details

Quality Control

Our 3-n-Fmoc-3-(4-Fluorophenyl)Propionic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide comprehensive Certificates of Analysis (COA) with each shipment to ensure traceability and compliance with your research or cGMP-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to maintain product integrity and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.