Description

4-Chloro-2-(Trifluoromethyl)Pyrimidine-5-Carboxylic Acid is a high-value, multifunctional heterocyclic building block essential for modern synthetic chemistry. Its core value lies in the strategic combination of a reactive chloro substituent, a stable trifluoromethyl group, and a versatile carboxylic acid functionality, enabling precise molecular construction. This compound is critically needed by research chemists and process developers in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly in the development of small-molecule drugs and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for constructing pyrimidine-based drug candidates, including kinase inhibitors, antiviral agents, and anticancer compounds.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides that leverage the biological activity of the pyrimidine scaffold.
• Material Science Research: Serves as a precursor for functionalized ligands, monomers, or additives in the development of advanced polymers and specialty materials.
• Chemical Biology & Proteomics: Employed as a building block for creating chemical probes, affinity tags, or linkers for studying biological systems.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and fine chemical companies for use in custom synthesis projects and scale-up campaigns.

Basic Information

Product Name	4-Chloro-2-(Trifluoromethyl)Pyrimidine-5-Carboxylic Acid
CAS No.	188781-49-9
Molecular Formula	C6H2ClF3N2O2
Molecular Weight	226.54 g/mol
Synonyms	5-Pyrimidinecarboxylic acid, 4-chloro-2-(trifluoromethyl)-; 4-Chloro-2-trifluoromethylpyrimidine-5-carboxylic acid; 2-(Trifluoromethyl)-4-chloropyrimidine-5-carboxylic acid; 188781-49-9; 4-Chloro-2-(trifluoromethyl)-5-pyrimidinecarboxylic acid
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-(Trifluoromethyl)Pyrimidine-5-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) detailing all specifications are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.